Changes in Behavior and Brain
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4 of 6 monkeys on OLZ
>>
aggressive
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2 of 6 monkeys on HAL
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aggressive
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atrophy of cortex/cerebellum/brainstem
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HAL
9% lower volume of brain
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9% decreased brain weight
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OLZ
10.5% lower volume of brain
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11%
decreased brain weight
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Several important behavioral and anatomical effects were observed.
First, all of the animals appeared to develop an aversion to the taste and/or subjective effects of the medications.
Second, a significant number of monkeys became aggressive during the study
(2/3 of the olanzapine recipients, 1/3 of the haloperidol recipients).
Third, chronic exposure to haloperidol and olanzapine resulted in comparable and diffuse reductions in brain volume and brain weight.