Experiment
•18 adult male macaques (4.5 to 5.3 yrs old)
•
•oral doses of haloperidol or placebo (27 months)
•oral doses of olanzapine                   (17 months)
•
•relevant doses of drugs vis-à-vis human therapy
• 1-1.5 ng/mL for HAL
• 10-25 ng/mL for OLZ
•
Study Design:
The experiment exposed 18 adult male macaques (4.5 to 5.3 years of age) to clinically relevant, oral doses of haloperidol (Haldol), olanzapine (Zyprexa), or placebo (sucrose pellets).

Animals received treatment for approximately 1.5 to 2 years.

Medications were administered once a day, in order to produce serum drug levels equivalent to those which occur in human patients at clinically recommended doses.

At the end of the experiment, the animals were sacrificed.  The brains of the medicated animals were compared to the brains of the drug-free controls.