•2002 Bozikas – 18 schizophrenia patients vs. 14 age-matched controls
• patients had 400% á tangle density in cortex (layer II of EC)
• patients had á plaque density (throughout the brain)
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•2005 Ballard et al – studied 40 patients with Lewy body dementia
• 23 patients avoided antipsychotic drugs
• 17 patients received antipsychotics
• when compared to the other patients, the 17 drug-consumers exhibited:
• 30%        higher density of cortical plaques
• 65-367%     higher density of tangles
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