Outcomes Based Upon Continuing
Use of Drugs vs. Placebo
• APs PBO
•% surviving
•1 year 75% 79%
•2 year 46% 71%
•3 year 30% 59%
•3 ½ years 26% 53%
•
•
•APs = antipsychotic drugs        
•PBO = placebo
Researchers were able to compare outcomes (mortality and survival rates) over a follow-up period of 1 to 3 ½ years.

Regardless of the duration of follow-up, the highest mortality rates occurred among the chronic users of antipsychotics:  25% were dead within 1 year,
74% were dead within 3 ½ years.

In contrast, the cessation of antipsychotic drug therapy was associated with significantly higher rates of survival:  79% surviving at 1 year, 47% surviving after 3 ½ years.



Key Point:
The withdrawal of antipsychotic drug therapy from demented patients was associated with significantly higher rates of extended survival.