DART-AD
Ballard et al (2009)
Ø 165 patients were randomly assigned to
•antipsychotic (83) or placebo (82)
•
Ø Assessed patients according to treatment
•fidelity (compliance) and outcome…
•
Ø Primary outcome: 12-month mortality
•
•
See full size image See full size image
Study design:
The researchers randomly assigned 165 patients to two groups:  in one group, 83 patients were continued on antipsychotic drug therapy;  in the second group, 82 patients were switched to placebo (inert pill).

The investigators carefully monitored the patients for compliance with the new treatments.

Primary outcome:           1-year mortality